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Endexx Initiates Adaptive Clinical Study With Proprietary CBD Capsule Formulation to Address Neuropathic Pain

Endexx Initiates Adaptive Clinical Study With Proprietary CBD Capsule Formulation to Address Neuropathic Pain

Endexx Initiates Adaptive Clinical Study With Proprietary CBD Capsule Formulation to Address Neuropathic Pain

Endexx Corporation (OTC PINK: EDXC), a provider of innovative hemp derived phyto-nutrients and nutritional products, has announced the launch of a doctor supervised, adaptive clinical study to test the efficacy of its proprietary CBD capsule in response to patients suffering from neuropathic pain.

Dr. Martin Pressman, DPM in New Haven, Connecticut, Dr. Daniel Brandwein, DPM in Weston, Florida, Dr. Michael Horwitz, DPM and Dr. Daniel Kiddy, DPM, both in St Louis, Missouri will enroll twenty patients into four groups, for a one month study using CBD enriched capsules to evaluate neuropathic pain reduction.

The proprietary formulations are pharmacist formulated and manufactured capsules which include a dual pack as a day and night formula with cannabidiol as its primary active ingredient. Each patient will be taking two capsules a day with results to be monitored. At the end of the study, findings will be subjected to an independent peer review board.

This study is an extension of the work conducted by Dr. Kiddy with his patients and a follow up of Dr. Brandwein’s research that demonstrated an average pain reduction after 2 weeks of usage from 7 to 8 down to 3 to 4 on a pain scale of 1 to 10, using 4 to 5 drops of CBD-rich hemp oil twice a day.

Dr. Brandwein stated, “I am very excited about the upcoming new trial where we can follow the information even closer. I also believe that in a capsule form, patients will be more compliant and have better results. In some cases, my patients have decreased and discontinued their usage of Neurontin and Gabapentin.”

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Study Shows Cannabidiol Can Heal Bone Fractures and Makes Bones Stronger

Study Shows Cannabidiol Can Heal Bone Fractures and Makes Bones Stronger

A study published in the Journal of Bone and Mineral Research by Tel Aviv University and Hebrew University researchers explores another promising new medical application for Cannabidiol. According to the research, the administration of the non-psychotropic component cannabinoid cannabidiol (CBD) significantly helps heal bone fractures. The study found that CBD markedly enhanced the healing process after bone fractures and made bones stronger.

The research indicates the undeniable clinical potential of CBD in regulating bone mass and the maintenance of bone health. The recent findings on bone fracture healing have given the medical world the biochemical proof that it’s been looking for. CBD stimulates bone-building cells to express the genes involved in producing the primary enzyme involved in bone healing, and this is an important step forward in the quest to learn more about the impact of cannabis on human health.

The findings strongly suggest that CBD can be supportive in the healing and recovery process of sports injuries and in the treatment or prevention of skeletal degeneration conditions associated with aging, particularly bone loss, rheumatoid arthritis and osteoporosis that affect 44 million Americans and 55% of people aged 50 or older.

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CBD, an all-natural compound that will help in reducing your stress level, strengthen your autoimmune system and may even help in the treatment of breast cancer.

It is well known that not all diseases affect women and men equally. Certain types of conditions occur at a higher rate or frequency in women. Moreover, in most cases, the increased risk factors that women are facing are not necessarily gender related.

Here are some of the known facts:
• 75% of people affected by autoimmune diseases are women; Those inflammatory conditions including rheumatoid arthritis, multiple sclerosis, lupus and many other chronic illnesses which in turn lead to an increased risk of heart disease for women.
• 18% of women in the US suffer from migraine headaches; Migraines affect three women for every one man;
• For Alzheimer’s disease, the ratio is two to one; this neurodegenerative condition kills nearly 60,000 women every year.
• Women are up to 40% more likely than men to develop mental health conditions, according to new analysis by a clinical psychologist at Oxford University; women are approximately 75% more likely than men to report having recently suffered from depression, and around 60% more likely to report an anxiety disorder.
• Breast cancer affects twelve percent of women in the US during the course of their lifetime with just under a quarter million new cases expected to be diagnosed this year alone, according to breastcancer.org.
What if nature provided us with a magic formulation and created a molecule with the ability to alleviate the symptoms, treat or even prevent the onset of the majority of the conditions listed above that disproportionately affect women and for which treatment options are at best palliative and rife with adverse side effects that severely compromise one’s quality of life?

The answer may surprise you but nature has already given our bodies the ability to produce this molecule along with many others which, acting together, work to attain and maintain homeostasis. Homeostasis is defined as the innate tendency to seek and maintain a condition of balance and equilibrium within its internal environment, even when faced with external changes.

This system is called the EndoCannabinoid System (ECS) and Cannabidiol (CBD) is one of the naturally occurring cannabinoids it produces.

These cannabinoids stimulate the body’s cannabinoid receptors, CB1 and CB2. It is these receptors that engage in “retrograde signaling,” a unique form of inter-cellular communication that inhibits immune response, reduces inflammation, relaxes musculature, lowers blood pressure, dilates bronchial passages, increases cerebral blood flow and normalizes over-stimulated nerves.

The EndoCannabinoid System is a system within the body that controls the way the body reacts to normal physiological processes. This molecular signaling system controls how the human body experiences pain, stress, hunger, sleep, circadian rhythms, blood pressure, body temperature, bone density, fertility, intestinal health, mood, metabolism, memory retention, and more.

CBD was isolated in 1963, lacks psychoactivity (it does not make you high), and does not appear to bind to CB1 or CB2 receptors, but rather interacts with a multitude of various ion channels, enzymes, and other receptors that are felt to explain its potential analgesic, antiepileptic, anti-nausea, anti-emetic, anti-inflammatory, anxiolytic, anti-psychotic, and anti-ischemic properties.

Its potential analgesic and anti-inflammatory effect is several hundred times more potent than aspirin in animal studies. CBD also has strong anti-oxidant actions and has been shown to reduce neurotoxicities.

Cannabidiol has been shown in multiple clinical studies and research papers to be helpful in the prevention and/or treatment of the following conditions:
• Epilepsy
• Cancer
• Neuropathic pain
• Arthritic pain
• Muscle spasms
• Inflammation
• Oxidative Stress
• Trauma
• Anxiety
• Psychosis
• Depression
• Schizophrenia
• Psoriasis
• Multiple Sclerosis
• Alzheimer’s
Cannabidiol is extracted from the hemp plant and grown under license from the Department of Agriculture. CBD is available commercially in oil form, in tinctures and topical ointments and creams.

For more information on clinical studies and research papers, click her. NCBI and PubMed are branches of the National Institutes of Health (NIH).

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